- Location : Spring House, Pennsylvania
- Category : R&D
Janssen Research and Development, L.L.C., a member of Johnson and Johnson’s Family of Companies, is recruiting for a Scientist, Translational Sciences (TS), Immunology Translational Sciences and Medicine (TSM) to be located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.
Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.JanssenRnD.com for more information.
We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
Janssen Immunology has a history of bringing life-changing therapies to patients with immune-mediated diseases.
Translational Sciences and Medicine (TSM) is an integrated group of scientists composed of a clinical Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies, and a Translational Sciences (TS) team which uses human based data and tissues to support the end to end portfolio. Together, the TSM group will provide the key learnings/insights on the next wave of novel therapies for these patients. Organizationally, TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group. TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases.
TS has a broad remit stretching from support of discovery with human data to support target selection, through development of novel decision- making biomarkers for early phase clinical trials, target-centric indication sequencing and prioritization, and biomarker support of regulatory filings. It has expertise in biomarker development, disease biology research and in the application of immunology and data science technologies to support drug discovery and development.
This position is in Immunology Translational Science department within the Systems Immunology team. The role will involve working with the wider Translational Sciences team to support our activities in the identification and development of biomarkers associated with therapeutic response, patient stratification, and molecular endpoints of disease. The candidate will analyze biomarker data sets, including bulk and single cell transcriptomic, genetic, proteomic, and microbiome data generated in clinical studies. The position will require the analysis of multidimensional high content data sets, integration of these data sets with clinical metadata, and pathway analysis of differentially modulated biomarkers so as to enable decisions around drug development.
The candidate must have strong analytical skills and experience with high-dimensional data. Experience with predictive models and biomarker discovery is highly desired. Familiarity with human translational research, clinical studies, and patient samples is also a positive attribute. The candidate must have a background in biology or immunology and be proficient in the biological interpretation of data. Data analysis will focus on systems biology and network pharmacology approaches. Impactful analysis will be used to enable decisions pertaining to efficacy and safety of compounds, dose selection, indication exploration for targets and compounds, and identification of predictive biomarkers for patient stratification. The successful candidate will be expected to represent the department on cross-functional teams and develop and implement biomarker strategies for compounds in the pipeline.
Responsibilities are as follows:
• Design and execute translational science and biomarker analysis plans integrating both disease and pathway approaches to support portfolio programs
• Contribute to the strategies on molecular understanding of human diseases, patient stratification and biomarker-based endpoint translational strategies
• Effective communication of study results to guide stakeholders in applying those results to making strategic decisions
• Work closely with key leaders in partner functions to ensure project goals are met
• Ph.D. with 1-3 years of relevant experience is required, preferably in pharmaceutical or biotechnology sectors
• Experience in Computational Biology, Immunology, Biomedical Engineering, Bioinformatics or a related field
• Strong computational skills and expertise in analyzing large datasets, e.g. scRNA-seq, transcriptomics, genetics, proteomics, microbiome, CYTOF, flow cytometry etc.
• Proficiency in standard analytical platforms (e.g., R, Python, RShiny, Dash, etc).
• Experience in the integration of –omics datasets and expertise in predictive algorithms, biomarker discovery and/or diagnostic development.
• Proficiency in biology/immunology, preferably in immune mediated diseases, and in the biological interpretation of data.
• Good communication and writing skills.
• Good organization skills and ability to handle multiple projects simultaneously is essential.
Johnson & Johnson Family of Companies are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by law.
*SOURCE : https://jobs.jnj.com/jobs/2711200914?lang=en&src=JB-10280